novoPT™
novoPT™ brings polyketide chemistry to human biology
novoPT™ (novel optimised Polyketide Therapeutics)
Until now, polyketides have been underexploited as drug discovery leads because they have been difficult to optimise. With novoPT™ Biotica has changed that, developing a repeatable, scalable process which spans lead identification through lead optimisation to manufacturing development.
Human biology-rich drug leads
Polyketides are great starting points for drug discovery. They are “high-content chemistry” – rich in biological properties relevant to human disease. More…
Lead identification using novoPT™ polyketide library
Biotica has assembled a library of naturally-occurring polyketides – these are pure compounds of known structure, selected to be amenable to optimization using Biotica’s technology. This expanding library of naturally-occurring polyketides is a resource for identification of novel optimizable leads. More…
novoPT™ lead optimisation
In lead optimisation, Biotica genetically alters a polyketide-producing micro-organism so that it produces a new polyketide compound. novoPT™ accesses novel chemical space, so novoPT™ compounds are patentable NCEs as well as being biologically differentiated. novoPT™creates a targeted library of analogues, from which Biotica selects a drug candidate. More…
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Links to papers describing novoPT™ and its applications
